Gene

sppl2

ID
ZDB-GENE-030131-4265
Name
signal peptide peptidase-like 2
Symbol
sppl2 Nomenclature History
Previous Names
  • wu:fc16e01
  • wu:fc85d12
  • zgc:136525
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have aspartic endopeptidase activity, intramembrane cleaving. Involved in negative regulation of coagulation. Predicted to localize to bounding membrane of organelle and integral component of endoplasmic reticulum membrane.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Krawitz et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Pickart et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sppl2 Human Ortholog
No data available
Associated With sppl2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003137 PA domain
Family IPR006639 Presenilin/signal peptide peptidase
Family IPR007369 Peptidase A22B, signal peptide peptidase
Homologous_superfamily IPR046450 PA domain superfamily
Domain Details Per Protein
Protein Length PA domain PA domain superfamily Peptidase A22B, signal peptide peptidase Presenilin/signal peptide peptidase
UniProtKB:F1QYI0 555
UniProtKB:A0A8M9QFY1 504
UniProtKB:A0A8M9QFX8 529
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sppl2-201 (1) Ensembl 2,851 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations