Gene
trap1
- ID
- ZDB-GENE-030131-4257
- Name
- TNF receptor-associated protein 1
- Symbol
- trap1 Nomenclature History
- Previous Names
-
- fc85a11
- wu:fc85a11
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables ATP hydrolysis activity; identical protein binding activity; and metal ion binding activity. Involved in nucleic acid phosphodiester bond hydrolysis. Predicted to be active in mitochondrial inner membrane. Orthologous to human TRAP1 (TNF receptor associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015316Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024399Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zf3519 | Allele with one deletion | Exon 6 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR020575 | Heat shock protein Hsp90, N-terminal |
| Family | IPR001404 | Heat shock protein Hsp90 family |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
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Domain Details Per Protein
| Protein | Length | Heat shock protein Hsp90 family | Heat shock protein Hsp90, N-terminal | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | HSP90, C-terminal domain | Ribosomal protein uS5 domain 2-type superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WFV1
|
719 | ||||||
|
UniProtKB:F1Q9X9
|
719 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-137D22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-29P9 | ZFIN Curated Data | |
| Encodes | EST | fc85a11 | ||
| Encodes | cDNA | MGC:171805 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198357 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198361 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113625 (1) | 3073 nt | ||
| Genomic | GenBank:CR846080 (2) | 242078 nt | ||
| Polypeptide | UniProtKB:A8WFV1 (1) | 719 aa |
- Fu, J.L., Zheng, S.Y., Wang, Y., Hu, X.B., Xiao, Y., Wang, J.M., Zhang, L., Wang, L., Nie, Q., Hou, M., Bai, Y.Y., Gan, Y.W., Liang, X.M., Xie, L.L., Li, D.W. (2023) HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221522120e2221522120
- Laquatra, C., Sanchez-Martin, C., Dinarello, A., Cannino, G., Minervini, G., Moroni, E., Schiavone, M., Tosatto, S., Argenton, F., Colombo, G., Bernardi, P., Masgras, I., Rasola, A. (2021) HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Cell Death & Disease. 12:434
- Faienza, F., Lambrughi, M., Rizza, S., Pecorari, C., Giglio, P., Salamanca Viloria, J., Allega, M.F., Chiappetta, G., Vinh, J., Pacello, F., Battistoni, A., Rasola, A., Papaleo, E., Filomeni, G. (2020) S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli. Biochemical pharmacology. 176:113869
- Mader, S.L., Lopez, A., Lawatscheck, J., Luo, Q., Rutz, D.A., Gamiz-Hernandez, A.P., Sattler, M., Buchner, J., Kaila, V.R.I. (2020) Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90. Nature communications. 11:1410
- Sanchez-Martin, C., Moroni, E., Ferraro, M., Laquatra, C., Cannino, G., Masgras, I., Negro, A., Quadrelli, P., Rasola, A., Colombo, G. (2020) Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1. Cell Reports. 31:107531
- Elnatan, D., Agard, D.A. (2018) Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. The Journal of biological chemistry. 293:13717-13724
- Verkhivker, G.M. (2018) Dynamics-based community analysis and perturbation response scanning of allosteric interaction networks in the TRAP1 chaperone structures dissect molecular linkage between conformational asymmetry and sequential ATP hydrolysis. Biochimica et biophysica acta. Proteins and proteomics. 1866:899-912
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elnatan, D., Betegon, M., Liu, Y., Ramelot, T., Kennedy, M.A., Agard, D.A. (2017) Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. eLIFE. 6
- Li, Y., Zhang, Y., Wang, T., Podok, P., Xu, D., Lu, L. (2015) Proteomic identification and characterization of Ctenopharyngodon idella tumor necrosis factor receptor-associated protein 1 (CiTrap1): an anti-apoptosis factor upregulated by grass carp reovirus infection. Fish & shellfish immunology. 43(2):449-59
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