Gene
kmt2e
- ID
- ZDB-GENE-030131-4120
- Name
- lysine (K)-specific methyltransferase 2E
- Symbol
- kmt2e Nomenclature History
- Previous Names
-
- mll5
- wu:fc74b02
- zgc:64223
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Is expressed in central nervous system; intermediate cell mass of mesoderm; and telencephalon. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64223 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| O'Donnell-Luria-Rodan syndrome | 618512 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR044434 | KMT2E, SET domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | KMT2E, SET domain | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BC51
|
1598 | ||||||||
|
UniProtKB:A0A8N7UVB9
|
1631 | ||||||||
|
UniProtKB:A0A8M9Q6C7
|
1655 | ||||||||
|
UniProtKB:A0A8M2BC59
|
1622 |
Interactions and Pathways
No data available
Plasmids
No data available