Gene
nsun2
- ID
- ZDB-GENE-030131-4017
- Name
- NOP2/Sun RNA methyltransferase 2
- Symbol
- nsun2 Nomenclature History
- Previous Names
-
- wu:fc65a08
- zgc:55517
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55517 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 5 | Alliance | Intellectual developmental disorder, autosomal recessive 5 | 611091 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001678 | SAM-dependent methyltransferase RsmB-F/NOP2-type domain |
| Domain | IPR049560 | SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core |
| Family | IPR023267 | RNA (C5-cytosine) methyltransferase |
| Family | IPR023270 | tRNA (C5-cytosine) methyltransferase, NCL1 |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | RNA (C5-cytosine) methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily | SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core | SAM-dependent methyltransferase RsmB-F/NOP2-type domain | tRNA (C5-cytosine) methyltransferase, NCL1 |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZTI1
|
706 | |||||
|
UniProtKB:A5PMI3
|
766 |
Interactions and Pathways
No data available
Plasmids
No data available