Gene

tnika

ID

ZDB-GENE-030131-3767

Name

TRAF2 and NCK interacting kinase a

Symbol

tnika Nomenclature History

Previous Names

tnikl
fc52d11
misshapen 1 (1)
msn1 (1)
wu:fc52d11
zgc:63535

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in convergent extension involved in gastrulation and regulation of cell shape. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in nervous system and neural tube. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63535 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Koppen et al., 2006
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnika Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 54	Alliance	Intellectual developmental disorder, autosomal recessive 54	617028

Associated With tnika Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR051700	STE20 Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Citron homology (CNH) domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	STE20 Ser/Thr Protein Kinase
UniProtKB:A0A8M2BAL9 InterPro	1297
UniProtKB:A0A8M2BAG3 InterPro	858
UniProtKB:A0A8M2BAK0 InterPro	1326
UniProtKB:A0A0R4IEP9 InterPro	1332
UniProtKB:Q7SY42 InterPro	1303
UniProtKB:A0A8M2BAL6 InterPro	1419
UniProtKB:A0A8M2BAT5 InterPro	1390
UniProtKB:A0A8M2BAF9 InterPro	1413