Gene

sema7a

ID

ZDB-GENE-030131-3633

Name

semaphorin 7A (JohnMiltonHagen blood group)

Symbol

sema7a Nomenclature History

Previous Names

fc47g07
wu:fc47g07 (1)
zgc:174881 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have chemorepellent activity; integrin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of macrophage cytokine production; and regulation of axon extension. Predicted to localize to integral component of plasma membrane. Is expressed in Purkinje cell. Orthologous to human SEMA7A (semaphorin 7A (John Milton Hagen blood group)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Takeuchi et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sema7a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Cholestasis, progressive familial intrahepatic, 11	619874
		[Blood group, John-Milton-Hagen system]	614745

Associated With sema7a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001627	Sema domain
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR016201	PSI domain
Family	IPR027231	Semaphorin
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036352	Sema domain superfamily
Repeat	IPR002165	Plexin repeat