Gene

gtf2b

ID

ZDB-GENE-030131-3544

Name

general transcription factor IIB

Symbol

gtf2b Nomenclature History

Previous Names

wu:fc44c11
zgc:66258

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II core complex assembly; protein acetylation; and transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within transcription preinitiation complex assembly. Predicted to be part of transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human GTF2B (general transcription factor IIB).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66258 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gtf2b Human Ortholog

No data available

Associated With gtf2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023486	Transcription factor TFIIB, conserved site
Domain	IPR013137	Zinc finger, TFIIB-type
Domain	IPR013150	Transcription factor TFIIB, cyclin-like domain
Domain	IPR013763	Cyclin-like domain
Family	IPR000812	Transcription factor TFIIB
Homologous_superfamily	IPR036915	Cyclin-like superfamily