Gene

chfr

ID

ZDB-GENE-030131-3522

Name

checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

Symbol

chfr Nomenclature History

Previous Names

fc43f10
si:dkey-69h6.7 (1)
wu:fc43f10

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable nucleotide binding activity and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell division. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in central nervous system and presumptive diencephalon. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159190 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chfr Human Ortholog

No data available

Associated With chfr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR040909	E3 ubiquitin-protein ligase CHFR, cysteine rich domain with multizinc binding
Family	IPR052256	E3 ubiquitin-protein ligase CHFR
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type