Gene
stag2a
- ID
- ZDB-GENE-030131-3432
- Name
- STAG2 cohesin complex component a
- Symbol
- stag2a Nomenclature History
- Previous Names
-
- fc39a01
- si:dkeyp-20g2.6 (1)
- wu:fc39a01
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in Mullegama-Klein-Martinez syndrome and holoprosencephaly. Orthologous to human STAG2 (stromal antigen 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Ketharnathan et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9551 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11496 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13330 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20396 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33585 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Holoprosencephaly 13, X-linked | Alliance | Holoprosencephaly 13, X-linked | 301043 |
| Mullegama-Klein-Martinez syndrome | Alliance | Mullegama-Klein-Martinez syndrome | 301022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Cohesin subunit Scc3/SA | STAG | Stromalin conservative domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B9I6
|
1245 | ||||
|
UniProtKB:A0A8M1NE13
|
1246 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stag2a-201
(1)
|
Ensembl | 5,371 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-20G2 | ZFIN Curated Data | |
| Encodes | EST | fc39a01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100028 (1) | 5371 nt | ||
| Genomic | GenBank:CR926467 (1) | 153796 nt | ||
| Polypeptide | UniProtKB:A0A8M1NE13 (1) | 1246 aa |
- Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
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