Gene
plod1a
- ID
- ZDB-GENE-030131-3165
- Name
- procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a
- Symbol
- plod1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable procollagen-lysine 5-dioxygenase activity. Acts upstream of or within fin morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of collagen trimer. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including cranium; notochord; otic vesicle; pectoral fin; and shield. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Durán et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ehlers-Danlos syndrome kyphoscoliotic type 1 | Alliance | Ehlers-Danlos syndrome, kyphoscoliotic type, 1 | 225400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001006 | Procollagen-lysine 5-dioxygenase, conserved site |
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR006620 | Prolyl 4-hydroxylase, alpha subunit |
| Domain | IPR044861 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain |
| Family | IPR050757 | Collagen-modifying Glycosyltransferase 25 |
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
Domain Details Per Protein
| Protein | Length | Collagen-modifying Glycosyltransferase 25 | Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain | Nucleotide-diphospho-sugar transferases | Oxoglutarate/iron-dependent dioxygenase domain | Procollagen-lysine 5-dioxygenase, conserved site | Prolyl 4-hydroxylase, alpha subunit |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WIN7
|
730 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
plod1a-203
(1)
|
Ensembl | 664 nt | ||
| mRNA |
plod1a-201
(1)
|
Ensembl | 2,767 nt | ||
| ncRNA |
plod1a-003
(1)
|
Ensembl | 406 nt |
Interactions and Pathways
No data available
Plasmids
No data available