Gene

sgk1

ID

ZDB-GENE-030131-2860

Name

serum/glucocorticoid regulated kinase 1

Symbol

sgk1 Nomenclature History

Previous Names

sgk (1)
cb1083 (1)
wu:fc20a09

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Acts upstream of or within inflammatory response. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blood vasculature; epidermal cell; epiphysis; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb1083 (17 images)
IMAGE:6912555 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sgk1 Human Ortholog

No data available

Associated With sgk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR017892	Protein kinase, C-terminal
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	Protein kinase, ATP binding site	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M2B9J1 InterPro	414
UniProtKB:Q7ZTW4 InterPro	433
UniProtKB:A0A8M2B972 InterPro	415
UniProtKB:A0A8M2B9E4 InterPro	598

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sgk1-201 (1) Ensembl	Ensembl	2,320 nt	Select Tool ZFIN BLAST
mRNA	sgk1-202 (1) Ensembl	Ensembl	845 nt	Select Tool ZFIN BLAST
mRNA	sgk1-203 (1) Ensembl	Ensembl	799 nt	Select Tool ZFIN BLAST
mRNA	sgk1-204 (1) Ensembl	Ensembl	1,143 nt	Select Tool ZFIN BLAST
ncRNA	sgk1-004 (1) Ensembl	Ensembl	649 nt	Select Tool ZFIN BLAST
ncRNA	sgk1-006 (1) Ensembl	Ensembl	844 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations