Gene
eif2s1b
- ID
- ZDB-GENE-030131-283
- Name
- eukaryotic translation initiation factor 2, subunit 1 alpha b
- Symbol
- eif2s1b Nomenclature History
- Previous Names
-
- eif2s1
- fb19d01
- wu:fb19d01 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytoplasm. Predicted to be part of several cellular components, including eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; and eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including immature eye; musculature system; nervous system; pharyngeal arch 3-7 skeleton; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56347 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003029 | S1 domain |
| Domain | IPR044126 | IF2a, S1-like domain |
| Family | IPR011488 | Translation initiation factor 2, alpha subunit |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR024054 | Translation initiation factor 2, alpha subunit, middle domain superfamily |
| Homologous_superfamily | IPR024055 | Translation initiation factor 2, alpha subunit, C-terminal |
Domain Details Per Protein
| Protein | Length | IF2a, S1-like domain | Nucleic acid-binding, OB-fold | S1 domain | Translation initiation factor 2, alpha subunit | Translation initiation factor 2, alpha subunit, C-terminal | Translation initiation factor 2, alpha subunit, middle domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I9E9
|
315 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2s1b-201
(1)
|
Ensembl | 1,345 nt |
Interactions and Pathways
No data available
Plasmids
No data available