Gene
dyrk2
- ID
- ZDB-GENE-030131-2804
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
- Symbol
- dyrk2 Nomenclature History
- Previous Names
-
- fc18c09
- si:ch211-266a5.8
- wu:fa09g03
- wu:fc18c09
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in central nervous system; myotome; and spinal cord. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tanaka et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa30608 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4ITS5
|
598 | ||||||
|
UniProtKB:Q5RHV3
|
587 | ||||||
|
UniProtKB:A0A2R8QCS7
|
577 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266A5 | ZFIN Curated Data | |
| Encodes | EST | fa09g03 | ZFIN Curated Data | |
| Encodes | EST | fc18c09 | ||
| Encodes | cDNA | MGC:162783 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044833 (1) | 2916 nt | ||
| Genomic | GenBank:BX465210 (1) | 171708 nt | ||
| Polypeptide | UniProtKB:A0A0R4ITS5 (1) | 598 aa |
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Hensley, M.R., Chua, R.F., Leung, Y.F., Yang, J.Y., Zhang, G. (2016) Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One. 11:e0163229
- Rodius, S., Androsova, G., Götz, L., Liechti, R., Crespo, I., Merz, S., Nazarov, P.V., de Klein, N., Jeanty, C., González-Rosa, J.M., Muller, A., Bernardin, F., Niclou, S.P., Vallar, L., Mercader, N., Ibberson, M., Xenarios, I., Azuaje, F. (2016) Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Scientific Reports. 6:26822
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Morimura, R., Nozawa, K., Tanaka, H., and Ohshima, T. (2013) Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Developmental Neurobiology. 73(12):911-20
- Tanaka, H., Morimura, R., and Ohshima, T. (2012) Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Developmental Biology. 370(2):223-236
- Igawa, D., Sakai, M., Savan, R. (2006) An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Molecular immunology. 43(7):999-1009
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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