Gene
serpinc1
- ID
- ZDB-GENE-030131-264
- Name
- serpin peptidase inhibitor, clade C (antithrombin), member 1
- Symbol
- serpinc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within cellular response to estrogen stimulus and regulation of blood coagulation. Predicted to be active in extracellular space. Is expressed in liver; yolk; and yolk syncytial layer. Used to study disseminated intravascular coagulation. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1051 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Liu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| antithrombin III deficiency | Alliance | Thrombophilia 7 due to antithrombin III deficiency | 613118 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disseminated intravascular coagulation | serpinc1zf548/zf548 | standard conditions | Liu et al., 2014 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AYE3
|
450 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpinc1-201
(1)
|
Ensembl | 2,424 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-192M14 | ZFIN Curated Data | |
| Contains | SNP | rs3729172 | ZFIN Curated Data | |
| Contains | SNP | rs3729173 | ZFIN Curated Data | |
| Contains | SNP | rs3729174 | ZFIN Curated Data | |
| Contains | SNP | rs3729175 | ZFIN Curated Data | |
| Contains | SNP | rs3729176 | ZFIN Curated Data | |
| Contains | SNP | rs3729177 | ZFIN Curated Data | |
| Contains | SNP | rs3729178 | ZFIN Curated Data | |
| Encodes | EST | eu1051 | Thisse et al., 2005 | |
| Encodes | EST | fb18f10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182863 (1) | 2427 nt | ||
| Genomic | GenBank:BX908392 (1) | 179577 nt | ||
| Polypeptide | UniProtKB:Q8AYE3 (1) | 450 aa |
- Li, X., Yang, S., Zhang, X., Zhang, Y., Zhang, Y., Li, H. (2024) Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System. International Journal of Molecular Sciences. 25(11):
- Xie, C., Zheng, N., Li, M., Zhang, Z., Huang, D., Xiao, M., Chen, D., He, C., Zuo, Z., Chen, X. (2024) Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents. Toxics. 12(7):
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
- Grzegorski, S.J., Zhao, Y., Richter, C.E., Ku, C.J., Lavik, K.I., Paul, D., Morrissey, J.H., Shavit, J.A. (2022) Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis. PLoS Genetics. 18:e1010534e1010534
- Sheng, J., Meng, Q., Yang, Z., Guan, J., Zhao, Y., Zhang, J., Wang, Y., Zhao, L., Wang, Y. (2020) Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade. Phytomedicine : international journal of phytotherapy and phytopharmacology. 76:153263
- Hu, Z., Lavik, K.I., Liu, Y., Vo, A.H., Richter, C.E., Di Paola, J., Shavit, J.A. (2019) Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia. Journal of thrombosis and haemostasis : JTH. 17(4):607-617
- Schmid, S., Fent, K. (2019) 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environmental pollution (Barking, Essex : 1987). 259:113808
- Wu, T.S., Lin, Y.T., Huang, Y.T., Yu, F.Y., Liu, B.H. (2019) Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor. Chemosphere. 242:125143
- Wu, X.M., Cao, L., Hu, Y.W., Chang, M.X. (2019) Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish & shellfish immunology. 94:355-372
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