Gene
nxf1b
- ID
- ZDB-GENE-030131-2585
- Name
- nuclear RNA export factor 1b
- Symbol
- nxf1b Nomenclature History
- Previous Names
-
- nxf1
- im:7156527
- wu:fc12d06
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within mRNA transport. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156527 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3248Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la028334Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23951 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43658 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002075 | Nuclear transport factor 2 domain |
| Domain | IPR005637 | TAP C-terminal (TAP-C) domain |
| Domain | IPR015245 | Nuclear RNA export factor Tap, RNA-binding domain |
| Domain | IPR018222 | Nuclear transport factor 2, eukaryote |
| Family | IPR030217 | Nuclear RNA export factor |
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Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NTF2-like domain superfamily | Nuclear RNA export factor | Nuclear RNA export factor Tap, RNA-binding domain | Nuclear transport factor 2 domain | Nuclear transport factor 2, eukaryote | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | TAP C-terminal (TAP-C) domain | UBA-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q7H6
|
642 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198K5 | ZFIN Curated Data | |
| Encodes | EST | fc12d06 | ||
| Encodes | EST | IMAGE:7156527 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001923926 (1) | 2511 nt | ||
| Genomic | GenBank:BX465841 (1) | 190913 nt | ||
| Polypeptide | UniProtKB:F1Q7H6 (1) | 642 aa |
- Li, X., Guo, R., Yang, S., Zhang, X., Yin, X., Teng, L., Zhang, S., Ji, G., Li, H. (2022) Cd248a and Cd248b in zebrafish participate in innate immune responses. Frontiers in immunology. 13:970626
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Mihaljevic, I., Popovic, M., Zaja, R., Smital, T. (2016) Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). BMC Genomics. 17:626
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, B., Rekosh, D., Hammarskjold, M.L. (2015) Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns. RNA (New York, N.Y.). 21(3):426-37
- Hao, R., Bondesson, M., Singh, A.V., Riu, A., McCollum, C.W., Knudsen, T.B., Gorelick, D.A., and Gustafsson, J.Å. (2013) Identification of Estrogen Target Genes during Zebrafish Embryonic Development through Transcriptomic Analysis. PLoS One. 8(11):e79020
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Quiniou, S.M., Wilson, M., and Boudinot, P. (2011) Processing of fish Ig heavy chain transcripts: Diverse splicing patterns and unusual nonsense mediated decay. Developmental and comparative immunology. 35(9):949-58
- Zhang, Z.C., Satterly, N., Fontoura, B.M., Chook, Y.M. (2011) Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Molecular biology of the cell. 22:465746684657-68
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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