Gene
oxr1b
- ID
- ZDB-GENE-030131-2438
- Name
- oxidation resistance 1b
- Symbol
- oxr1b Nomenclature History
- Previous Names
-
- fc07g10
- si:dkeyp-84f11.5
- wu:fc07g10
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be involved in response to oxidative stress. Predicted to be active in nucleus. Is expressed in central nervous system; head; lateral line ganglion; and olfactory pit. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar hyplasia/atrophy, epilepsy, and global developmental delay | Alliance | Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay | 213000 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | LysM domain | LysM domain superfamily | TLDc domain |
|---|---|---|---|---|
|
UniProtKB:F1Q4W8
|
749 | |||
|
UniProtKB:A0A8M3AK20
|
240 | |||
|
UniProtKB:I3ISS4
|
841 | |||
|
UniProtKB:A0A8M2B610
|
814 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-216M24 | ZFIN Curated Data | |
| Contained in | BAC | CH73-312O15 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-84F11 | ZFIN Curated Data | |
| Encodes | EST | fc07g10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045203 (1) | 3660 nt | ||
| Genomic | GenBank:BX890617 (1) | 182182 nt | ||
| Polypeptide | UniProtKB:I3ISS4 (1) | 841 aa |
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Li, Y., Ning, G., Kang, B., Zhu, J., Wang, X.Y., Wang, Q., Cai, T. (2022) A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish. Human molecular genetics. 32(5):764-772
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Laroche, F.J., Tulotta, C., Lamers, G.E., Meijer, A.H., Yang, P., Verbeek, F.J., Blaise, M., Stougaard, J., and Spaink, H.P. (2013) The embryonic expression patterns of zebrafish genes encoding LysM-domains. Gene expression patterns : GEP. 13(7):212-24
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