Gene

dennd5b

ID

ZDB-GENE-030131-2248

Name

DENN/MADD domain containing 5B

Symbol

dennd5b Nomenclature History

Previous Names

id:ibd5082
wu:fc01g04
zgc:77218

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have Rab guanyl-nucleotide exchange factor activity. Predicted to localize to integral component of membrane. Is expressed in neural plate and tail bud. Orthologous to human DENND5B (DENN domain containing 5B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dennd5b Human Ortholog

No data available

Associated With dennd5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR001194	cDENN domain
Domain	IPR004012	RUN domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR037516	Tripartite DENN domain
Domain	IPR047277	DENN domain-containing protein 5A/B, PLAT/LH2 domain
Domain	IPR047292	DENN domain-containing protein 5B, second RUN domain
Domain	IPR047293	DENN domain-containing protein 5B, first RUN domain
Family	IPR047278	DENN domain-containing protein 5A/B
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily
Homologous_superfamily	IPR037213	RUN domain superfamily
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe

Domain Details Per Protein

Protein	Length	cDENN domain	dDENN domain	DENN domain-containing protein 5A/B	DENN domain-containing protein 5A/B, PLAT/LH2 domain	DENN domain-containing protein 5B, first RUN domain	DENN domain-containing protein 5B, second RUN domain	DENN domain, C-terminal lobe	PLAT/LH2 domain	PLAT/LH2 domain superfamily	RUN domain	RUN domain superfamily	Tripartite DENN domain	uDENN domain
UniProtKB:F1QQ55 InterPro	1325
UniProtKB:A0A8M2BC03 InterPro	1305
UniProtKB:Q6NXD8 InterPro	1311
UniProtKB:Z4YIY0 InterPro	1291
UniProtKB:A0A8M9Q5S1 InterPro	695

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dennd5b-201 (1) Ensembl	Ensembl	5,533 nt	Select Tool ZFIN BLAST
mRNA	dennd5b-202 (1) Ensembl	Ensembl	3,978 nt	Select Tool ZFIN BLAST
mRNA	dennd5b-203 (1) Ensembl	Ensembl	456 nt	Select Tool
mRNA	dennd5b-204 (1) Ensembl	Ensembl	5,510 nt	Select Tool
mRNA	dennd5b-205 (1) Ensembl	Ensembl	923 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations