Gene
cemip2
- ID
- ZDB-GENE-030131-2179
- Name
- cell migration inducing hyaluronidase 2
- Symbol
- cemip2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables hyalurononglucosaminidase activity. Involved in several processes, including heart development; hyaluronan catabolic process; and regulation of signal transduction. Acts upstream of or within heart development; muscle attachment; and positive regulation of extracellular matrix assembly. Located in plasma membrane. Is expressed in brain; cardiovascular system; fin bud; head mesenchyme; and otic vesicle. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu4800 | Allele with one point mutation | Unknown | Missense | ENU | |
| hu5935 | Allele with one point mutation | Exon 3 | Premature Stop | ENU | |
| sa2236 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13058 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33599 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sk38 | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| uq1ks | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uq2ks | Allele with one point mutation | Acceptor Splice Site of Intron 6 | Unknown | ENU |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cell surface hyaluronidase, PANDER-like domain | G8 domain | ILEI/PANDER domain | Pectin lyase fold/virulence factor |
|---|---|---|---|---|---|
|
UniProtKB:A3KPQ7
|
|||||
|
UniProtKB:G0ZDN6
|
1390 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cemip2-201
(1)
|
Ensembl | 6,698 nt | ||
| mRNA |
cemip2-202
(1)
|
Ensembl | 5,343 nt | ||
| mRNA |
cemip2-204
(1)
|
Ensembl | 6,761 nt | ||
| mRNA |
cemip2-205
(1)
|
Ensembl | 6,779 nt | ||
| ncRNA |
tmem2-002
(1)
|
Ensembl | 286 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24K20 | ZFIN Curated Data | |
| Encodes | EST | fa98g01 | ||
| Encodes | EST | fb99a08 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099449 (1) | 5343 nt | ||
| Genomic | GenBank:BX294191 (2) | 185868 nt | ||
| Polypeptide | UniProtKB:G0ZDN6 (1) | 1390 aa |
- Hernandez, L., Ryckebüsch, L., Wang, C., Ling, R., Yelon, D. (2019) Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(12):1195-1210
- Capon, S.J., Baillie, G.J., Bower, N.I., da Silva, J.A., Paterson, S., Hogan, B.M., Simons, C., Smith, K.A. (2017) Utilising polymorphisms to achieve allele-specific genome editing in zebrafish. Biology Open. 6(1):125-131
- De Angelis, J.E., Lagendijk, A.K., Chen, H., Tromp, A., Bower, N.I., Tunny, K.A., Brooks, A.J., Bakkers, J., Francois, M., Yap, A.S., Simons, C., Wicking, C., Hogan, B.M., Smith, K.A. (2017) Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell. 40:123-136
- Yamamoto, H., Tobisawa, Y., Inubushi, T., Irie, F., Oyama, C., Yamaguchi, Y. (2017) A Mammalian Homolog of the Zebrafish Transmembrane Protein 2 (TMEM2) Is the Long-sought-after Cell Surface Hyaluronidase. The Journal of biological chemistry. 292(18):7304-7313
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Ryckebüsch, L., Hernandez, L., Wang, C., Phan, J., Yelon, D. (2016) Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment. Development (Cambridge, England). 143(16):2965-72
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Smith, K.A., Lagendijk, A.K., Courtney, A.D., Chen, H., Paterson, S., Hogan, B.M., Wicking, C., and Bakkers, J. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development (Cambridge, England). 138(19):4193-4198
- Totong, R., Schell, T., Lescroart, F., Ryckebüsch, L., Lin, Y.F., Zygmunt, T., Herwig, L., Krudewig, A., Gershoony, D., Belting, H.G., Affolter, M., Torres-Vazquez, J., and Yelon, D. (2011) The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development (Cambridge, England). 138(19):4199-4205
- Cañestro, C., Catchen, J.M., Rodriguez-Mari, A., Yokoi, H., and Postlethwait, J.H. (2009) Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. PLoS Genetics. 5(5):e1000496
1 - 10 of 10
Show