Gene

setd2

ID

ZDB-GENE-030131-2140

Name

SET domain containing 2, histone lysine methyltransferase

Symbol

setd2 Nomenclature History

Previous Names

fb97h09
wu:fb97h09 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in histone H3-K36 trimethylation and regulation of transcription, DNA-templated. Predicted to localize to chromosome and nucleus. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Liu et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, autosomal dominant 70	620157
		Luscan-Lumish syndrome	616831
		Rabin-Pappas syndrome	620155

Associated With setd2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001202	WW domain
Domain	IPR001214	SET domain
Domain	IPR003616	Post-SET domain
Domain	IPR006560	AWS domain
Domain	IPR013257	Set2 Rpb1 interacting domain
Domain	IPR044437	SETD2/Set2, SET domain
Family	IPR042294	Histone-lysine N-methyltransferase SETD2, animal
Homologous_superfamily	IPR036020	WW domain superfamily
Homologous_superfamily	IPR038190	Set2 Rpb1 interacting domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	AWS domain	Histone-lysine N-methyltransferase SETD2, animal	Post-SET domain	Set2 Rpb1 interacting domain	Set2 Rpb1 interacting domain superfamily	SETD2/Set2, SET domain	SET domain	SET domain superfamily	WW domain	WW domain superfamily
UniProtKB:A0A8M9PJZ4 InterPro	2723
UniProtKB:F1QJI9 InterPro	2737

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	setd2-201 (1) Ensembl	Ensembl	9,903 nt	Select Tool
mRNA	setd2-202 (1) Ensembl	Ensembl	10,690 nt	Select Tool ZFIN BLAST
mRNA	setd2-203 (1) Ensembl	Ensembl	10,082 nt	Select Tool ZFIN BLAST
mRNA	setd2-204 (1) Ensembl	Ensembl	10,337 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations