Gene
hdlbpa
- ID
- ZDB-GENE-030131-2032
- Name
- high density lipoprotein binding protein a
- Symbol
- hdlbpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be part of polysome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; immature eye; and pectoral fin. Orthologous to human HDLBP (high density lipoprotein binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb591 (19 images)
- cb811 (19 images)
- IMAGE:7140982 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7582 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa14220 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33870 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40694 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab313 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily |
|---|---|---|---|---|
|
UniProtKB:Q7ZU44
|
1208 | |||
|
UniProtKB:A0A8M2BDG6
|
1272 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hdlbpa-201
(1)
|
Ensembl | 5,109 nt | ||
| mRNA |
hdlbpa-203
(1)
|
Ensembl | 1,495 nt | ||
| ncRNA |
hdlbpa-004
(1)
|
Ensembl | 823 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87O21 | ZFIN Curated Data | |
| Encodes | EST | cb591 | Thisse et al., 2001 | |
| Encodes | EST | cb811 | Thisse et al., 2001 | |
| Encodes | EST | fb36d01 | ZFIN Curated Data | |
| Encodes | EST | fb92e10 | Rauch et al., 2003 | |
| Encodes | EST | fb94h08 | ||
| Encodes | EST | fc23d06 | ZFIN Curated Data | |
| Encodes | EST | fc75h07 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140982 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55613 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201474 (1) | 5124 nt | ||
| Genomic | GenBank:BX957353 (2) | 186825 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDG6 (1) | 1272 aa |
- Wang, Y., Pan, Y., Hou, M., Luo, R., He, J., Lin, F., Xia, X., Li, P., He, C., He, P., Cheng, S., Song, Z. (2023) Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115736115736
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
- Knoll-Gellida, A., Andre, M., Gattegno, T., Forgue, J., Admon, A., and Babin, P.J. (2006) Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. BMC Genomics. 7(1):46
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Chen, J.Y., Chen, J.C., and Wu, J.L. (2003) Molecular cloning and functional analysis of zebrafish high-density lipoprotein-binding protein. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 136(1):117-130
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Ton, C., Hwang, D.M., Dempsey, A.A., Tang, H.C., Yoon, J., Lim, M., Mably, J.D., Fishman, M.C., and Liew, C.C. (2000) Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Genome research. 10(12):1915-1927
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