Gene
usp8
- ID
- ZDB-GENE-030131-1949
- Name
- ubiquitin specific peptidase 8
- Symbol
- usp8 Nomenclature History
- Previous Names
-
- wu:fb15f07
- wu:fb92h07
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitin-specific protease activity. Involved in regulation of cilium assembly. Predicted to localize to several cellular components, including extrinsic component of endosome membrane; midbody; and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ACTH-secreting pituitary adenoma | Alliance | Pituitary adenoma 4, ACTH-secreting, somatic | 219090 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR015063 | USP8 dimerisation domain |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Domain | IPR048498 | USP8, WW domain |
| Family | IPR050185 | Ubiquitin carboxyl-terminal hydrolase |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Rhodanese-like domain | Rhodanese-like domain superfamily | Ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain | USP8 dimerisation domain | USP8, WW domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P169
|
1067 | |||||||||
|
UniProtKB:A0A8M3ARQ7
|
1066 |
Interactions and Pathways
No data available
Plasmids
No data available