Gene
alpk2
- ID
- ZDB-GENE-030131-1868
- Name
- alpha-kinase 2
- Symbol
- alpk2 Nomenclature History
- Previous Names
-
- fb83b04
- si:ch211-233a1.1
- wu:fb83b04
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within epicardium morphogenesis; heart contraction; and heart development. Predicted to be located in basolateral plasma membrane. Is expressed in adaxial cell; primitive heart tube; and somite. Orthologous to human ALPK2 (alpha kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Hofsteen et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hofsteen et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf1093 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-alpk2 | Hofsteen et al., 2018 | |
| MO1-alpk2 | N/A | Hofsteen et al., 2018 |
| MO2-alpk2 | N/A | Hofsteen et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233A1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-277M11 | ZFIN Curated Data | |
| Encodes | EST | fb83b04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423781 (1) | 6738 nt | ||
| Genomic | GenBank:BX248399 (1) | 158884 nt | ||
| Polypeptide | RefSeq:NP_001410710 (1) |
- Hofsteen, P., Robitaille, A.M., Strash, N., Palpant, N., Moon, R.T., Pabon, L., Murry, C.E. (2018) ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience. 2:88-100
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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