Gene
exosc8
- ID
- ZDB-GENE-030131-1736
- Name
- exosome component 8
- Symbol
- exosc8 Nomenclature History
- Previous Names
-
- Opa-interacting protein 2 (3' exoribonuclease family) (1)
- wu:fb79a10
- zgc:110381
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within axonogenesis; cerebellar Purkinje cell layer structural organization; and myelination. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in alar plate midbrain region; immature eye; midbrain; and retina. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1C. Orthologous to human EXOSC8 (exosome component 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157503 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 1C | Alliance | Pontocerebellar hypoplasia, type 1C | 616081 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001247 | Exoribonuclease, phosphorolytic domain 1 |
| Domain | IPR015847 | Exoribonuclease, phosphorolytic domain 2 |
| Family | IPR033196 | Exosome complex component Rrp43 |
| Family | IPR050590 | Exosome complex component Rrp42 subfamily |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR027408 | PNPase/RNase PH domain superfamily |
| Homologous_superfamily | IPR036345 | Exoribonuclease, PH domain 2 superfamily |
Domain Details Per Protein
| Protein | Length | Exoribonuclease, PH domain 2 superfamily | Exoribonuclease, phosphorolytic domain 1 | Exoribonuclease, phosphorolytic domain 2 | Exosome complex component Rrp42 subfamily | Exosome complex component Rrp43 | PNPase/RNase PH domain superfamily | Ribosomal protein uS5 domain 2-type superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRN4
|
277 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
exosc8-201
(1)
|
Ensembl | 969 nt | ||
| ncRNA |
exosc8-002
(1)
|
Ensembl | 847 nt | ||
| ncRNA |
exosc8-003
(1)
|
Ensembl | 407 nt |
Interactions and Pathways
No data available
Plasmids
No data available