Gene

ewsr1b

ID

ZDB-GENE-030131-1600

Name

EWS RNA-binding protein 1b

Symbol

ewsr1b Nomenclature History

Previous Names

fb40b11 (1)
fusl
wu:fb40b11 (1)
wu:fb75g09
zgc:55864

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and transcription coregulator activity. Involved in central nervous system neuron development and mitotic cell cycle. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55864 (1 image)
MGC:113929 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Azuma et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ewsr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ewing sarcoma	Alliance	Ewing sarcoma	612219
Ewing sarcoma	Alliance	Neuroepithelioma	612219

Associated With ewsr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR001876	Zinc finger, RanBP2-type
Family	IPR034870	TAF15/EWS/TLS family
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	TAF15/EWS/TLS family	Zinc finger, RanBP2-type	Zinc finger, RanBP2-type superfamily
UniProtKB:Q4QRG0 InterPro	579
UniProtKB:A0A8M3B9G4 InterPro	311
UniProtKB:A0A8M2BCF1 InterPro	577

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ewsr1b-201 (1) Ensembl	Ensembl	2,083 nt	Select Tool
mRNA	ewsr1b-202 (1) Ensembl	Ensembl	2,441 nt	Select Tool
mRNA	ewsr1b-204 (1) Ensembl	Ensembl	897 nt	Select Tool
ncRNA	ewsr1b-003 (1) Ensembl	Ensembl	1,207 nt	Select Tool
ncRNA	ewsr1b-005 (1) Ensembl	Ensembl	780 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations