Gene

ddx3xa

ID

ZDB-GENE-030131-1565

Name

DEAD-box helicase 3 X-linked a

Symbol

ddx3xa Nomenclature History

Previous Names

ddx3
ddx3a
fb74g09
wu:fb74g09
zgc:158804

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and RNA helicase activity. Predicted to be involved in cell differentiation and gamete generation. Predicted to localize to P granule and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Mueller et al., 2010

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx3xa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, X-linked syndromic, Snijders Blok type	300958

Associated With ddx3xa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	ATP-dependent RNA helicase DEAD-box, conserved site	DEAD/DEAH box helicase domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	RNA helicase, DEAD-box type, Q motif
UniProtKB:A0A8M9QAW2 InterPro	792
UniProtKB:A0A8M6Z8G4 InterPro	728
UniProtKB:A0A8M9QFI7 InterPro	841
UniProtKB:A0A8M9QAW0 InterPro	825
UniProtKB:A0A8M2BF54 InterPro	693
UniProtKB:B0S6P6 InterPro	709
UniProtKB:A0A8M9QJS4 InterPro	784
UniProtKB:A0A8M6Z099 InterPro	728
UniProtKB:A0A8M9Q4N5 InterPro	840
UniProtKB:A0A8M9QFJ0 InterPro	813
UniProtKB:A0A8M9QFJ5 InterPro	713
UniProtKB:A0A8M3B2Q5 InterPro	708
UniProtKB:A0A8M9QJR9 InterPro	821
UniProtKB:A0A8M9PS93 InterPro	840
UniProtKB:A0A8M9Q4N8 InterPro	812
UniProtKB:A0A8M2BF62 InterPro	729