Gene
ubr3
- ID
- ZDB-GENE-030131-1473
- Name
- ubiquitin protein ligase E3 component n-recognin 3
- Symbol
- ubr3 Nomenclature History
- Previous Names
-
- fb72f06
- wu:fb72f06
- zmp:0000001279
- znf650 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within eye morphogenesis. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in somite. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Li et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Li et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1250 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| b1251 | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR | |
| sa2488 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10176 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16777 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17047 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31698 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34547 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41341 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 11
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase UBR1-like | E3 ubiquitin-protein ligase UBR-like, C-terminal | Zinc finger, RING-type | Zinc finger, UBR-type |
|---|---|---|---|---|---|
|
UniProtKB:F1QJX5
|
1863 | ||||
|
UniProtKB:A0A8M9Q4T2
|
1874 | ||||
|
UniProtKB:A0A8M9QB29
|
1862 | ||||
|
UniProtKB:A0A8M9QJY5
|
1851 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-344M4 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-384O24 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-417C18 | ZFIN Curated Data | |
| Encodes | EST | fb72f06 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423758 (1) | 6261 nt | ||
| Genomic | GenBank:LO017832 (1) | 59024 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q4T2 (1) | 1874 aa |
- Li, T., Fan, J., Blanco-Sánchez, B., Giagtzoglou, N., Lin, G., Yamamoto, S., Jaiswal, M., Chen, K., Zhang, J., Wei, W., Lewis, M.T., Groves, A.K., Westerfield, M., Jia, J., Bellen, H.J. (2016) Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genetics. 12:e1006054
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
1 - 3 of 3
Show