Gene
cel.1
- ID
- ZDB-GENE-030131-1201
- Name
- carboxyl ester lipase, tandem duplicate 1
- Symbol
- cel.1 Nomenclature History
- Previous Names
-
- basal.1 (1)
- fb62e11
- wu:fb62e11
- zgc:66457
- zgc:92042
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Is expressed in pancreas. Orthologous to human CEL (carboxyl ester lipase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66457 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 8 | Alliance | Maturity-onset diabetes of the young, type VIII | 609812 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019826 | Carboxylesterase type B, active site |
| Conserved_site | IPR019819 | Carboxylesterase type B, conserved site |
| Domain | IPR002018 | Carboxylesterase, type B |
| Family | IPR000997 | Cholinesterase |
| Family | IPR051093 | Neuroligin and Bile salt-activated lipase |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, active site | Carboxylesterase type B, conserved site | Cholinesterase | Neuroligin and Bile salt-activated lipase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SXC0
|
550 |
Interactions and Pathways
No data available
Plasmids
No data available