Gene
rock2a
- ID
- ZDB-GENE-030115-3
- Name
- rho-associated, coiled-coil containing protein kinase 2a
- Symbol
- rock2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have GTP-Rho binding activity and Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including gastrulation; protein catabolic process in the vacuole; and regulation of actin cytoskeleton organization. Localizes to plasma membrane. Is expressed in corneal epithelium; fin bud; midbrain hindbrain boundary; otic vesicle; and pharyngeal arch 3-7. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu609 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lisowska et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR015008 | ROCK, Rho binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR029878 | Rho-associated protein kinase 2, catalytic domain |
| Domain | IPR037311 | Rho-associated protein kinase 2, HR1 domain |
| Family | IPR020684 | Rho-associated protein kinase 1/2 |
| Family | IPR050839 | Rho-associated Serine/Threonine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Rho-associated protein kinase 1/2 | Rho-associated protein kinase 2, catalytic domain | Rho-associated protein kinase 2, HR1 domain | Rho-associated Serine/Threonine Kinase | ROCK, Rho binding domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90Y37
|
1375 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rock2a-201
(1)
|
Ensembl | 5,699 nt | ||
| mRNA |
rock2a-202
(1)
|
Ensembl | 4,191 nt |
Interactions and Pathways
No data available
Plasmids
No data available