Gene

lamb1a

ID

ZDB-GENE-021226-1

Name

laminin, beta 1a

Symbol

lamb1a Nomenclature History

Previous Names

lamb1
cb95 (1)
fc20b05
grumpy
gup
sb:cb95
wu:fc20b05

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable integrin binding activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; fin regeneration; and nervous system development. Predicted to be located in membrane. Predicted to be part of laminin complex. Is expressed in several structures, including digestive system; fin; nervous system; optic cup; and pectoral fin bud. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb95 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 64 figures from 24 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lamb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lissencephaly 5	Alliance	Lissencephaly 5	615191

Associated With lamb1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	lamb1a^m189/m189	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR013015	Laminin IV type B
Family	IPR050440	Laminin/Netrin Extracellular Matrix
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily