Gene
mc5rb
- ID
- ZDB-GENE-021223-4
- Name
- melanocortin 5b receptor
- Symbol
- mc5rb Nomenclature History
- Previous Names
-
- zMC5b
- zgc:194217
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14442 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melanocortin 5 receptor | Melanocortin/ACTH receptor | Melanocortin receptor 3-5 |
|---|---|---|---|---|---|---|
|
UniProtKB:F1Q9X6
|
328 | |||||
|
UniProtKB:Q8JGW1
|
328 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181C1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194196 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194217 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173280 (1) | 987 nt | ||
| Genomic | GenBank:CR848742 (1) | 177769 nt | ||
| Polypeptide | UniProtKB:F1Q9X6 (1) | 328 aa |
- Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
- Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7
- Zhu, M., Wang, M., Chen, Y., Zhang, C. (2019) Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Journal of molecular endocrinology.
- Liao, S., Dong, J., Xu, W., Xi, B., Tao, Y., Liu, B., Xie, J. (2018) Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Fish physiology and biochemistry. 45(1):311-321
- Wang, H., Semenova, S., Kuusela, S., Panula, P., Lehtonen, S. (2015) Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4435-48
- Renquist, B.J., Zhang, C., Williams, S.Y., and Cone, R.D. (2013) Development of an Assay for High-Throughput Energy Expenditure Monitoring in the Zebrafish. Zebrafish. 10(3):343-52
- Zhang, C., Forlano, P.M., and Cone, R.D. (2012) AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metabolism. 15(2):256-264
- Kumar, A., Bhandari, A., Sinha, R., Goyal, P., and Grapputo, A. (2011) Spliceosomal Intron Insertions in Genome Compacted Ray-Finned Fishes as Evident from Phylogeny of MC Receptors, Also Supported by a Few Other GPCRs. PLoS One. 6(8):e22046
- Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America. 107(47):20164-71
- Sánchez, E., Rubio, V.C., Thompson, D.A., Metz, J., Flik, G., Millhauser, G.L., and Cerda-Reverter, J.M. (2009) Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1293-R1306
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