Gene

mc4r

ID

ZDB-GENE-021223-2

Name

melanocortin 4 receptor

Symbol

mc4r Nomenclature History

Previous Names

zMC4
si:dkey-151m6.62

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in plasma membrane. Is expressed in brain; female organism; myotome; and primary motor neurons. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mc4r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Obesity (BMIQ20)	618406
		{Obesity, resistance to (BMIQ20)}	618406

Associated With mc4r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000155	Melanocortin 4 receptor
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR001671	Melanocortin/ACTH receptor
Family	IPR001908	Melanocortin receptor 3-5