Gene
msna
- ID
- ZDB-GENE-021211-2
- Name
- moesin a
- Symbol
- msna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have actin binding activity. Involved in blood vessel lumenization and endoderm development. Predicted to localize to cytoskeleton. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Orthologous to human MSN (moesin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2457 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 50 | Alliance | Immunodeficiency 50 | 300988 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR011259 | Ezrin/radixin/moesin, C-terminal |
| Domain | IPR018979 | FERM, N-terminal |
| Domain | IPR018980 | FERM, C-terminal PH-like domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR041789 | ERM family, FERM domain C-lobe |
| Domain | IPR046810 | Ezrin/radixin/moesin, alpha-helical domain |
| Family | IPR000798 | Ezrin/radixin/moesin-like |
| Family | IPR011174 | Ezrin/radixin/moesin |
| Homologous_superfamily | IPR008954 | Moesin tail domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | ERM family, FERM domain C-lobe | Ezrin/radixin/moesin | Ezrin/radixin/moesin, alpha-helical domain | Ezrin/radixin/moesin, C-terminal | Ezrin/radixin/moesin-like | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | Moesin tail domain superfamily | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I42
|
579 | ||||||||||||||||
|
UniProtKB:A0A8M3AZE1
|
443 | ||||||||||||||||
|
UniProtKB:A0A8M3B2A2
|
568 |
Interactions and Pathways
No data available
Plasmids