Gene
npm1a
- ID
- ZDB-GENE-021028-1
- Name
- nucleophosmin 1a
- Symbol
- npm1a Nomenclature History
- Previous Names
-
- npm1
- sb:cb487
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within hemopoiesis and regulation of apoptotic process. Located in nucleolus. Is expressed in several structures, including digestive system; fin bud; hematopoietic cell; nervous system; and neural tube. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb487 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bolli et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleophosmin, C-terminal | Nucleoplasmin core domain | Nucleoplasmin core domain superfamily | Nucleoplasmin family |
|---|---|---|---|---|---|
|
UniProtKB:E7FCU0
|
279 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npm1a-201
(1)
|
Ensembl | 481 nt | ||
| mRNA |
npm1a-202
(1)
|
Ensembl | 846 nt | ||
| mRNA |
npm1a-204
(1)
|
Ensembl | 1,615 nt | ||
| mRNA |
npm1a-205
(1)
|
Ensembl | 809 nt | ||
| ncRNA |
npm1a-002
(1)
|
Ensembl | 838 nt | ||
| ncRNA |
npm1a-003
(1)
|
Ensembl | 519 nt | ||
| ncRNA |
npm1a-004
(1)
|
Ensembl | 549 nt |
Interactions and Pathways
No data available
Plasmids
No data available