Gene
foxn1
- ID
- ZDB-GENE-021008-1
- Name
- forkhead box N1
- Symbol
- foxn1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in thymus development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Is expressed in pharyngeal arch; pharyngeal arch 3-7 skeleton; thymic epithelium; thymus; and thymus primordium. Orthologous to human FOXN1 (forkhead box N1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
T-cell immunodeficiency, congenital alopecia, and nail dystrophy | Alliance | T-cell immunodeficiency, congenital alopecia, and nail dystrophy | 601705 |
T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant | 618806 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047401 | Forkhead box protein N1, forkhead domain |
Family | IPR049624 | Forkhead box protein N1/4 |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Forkhead box protein N1/4 | Forkhead box protein N1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q7ZTC0
|
565 | ||||||
UniProtKB:F1R9K2
|
565 |
Interactions and Pathways
No data available
Plasmids
No data available