Gene
prrx1a
- ID
- ZDB-GENE-020905-5
- Name
- paired related homeobox 1a
- Symbol
- prrx1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including atrial cardiac muscle cell action potential; epithelial to mesenchymal transition; and heart looping. Predicted to be located in nucleus. Is expressed in several structures, including cranial vault; fin; gill; mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb329 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1246 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
| el558 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| el803 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hu13685 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hu13762 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa19740 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agnathia-otocephaly complex | Alliance | Agnathia-otocephaly complex | 202650 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired mesoderm homeobox protein 1/2 |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7T373
|
245 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prrx1a-201
(1)
|
Ensembl | 1,908 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(prrx1a:EGFP) |
|
| 1 | Rago et al., 2019 | |
| Tg(prrx1a:EGFP) |
|
| 2 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-218H11 | ZFIN Curated Data | |
| Encodes | EST | cb329 | Thisse et al., 2001 | |
| Encodes | EST | fa09h05 | ZFIN Curated Data | |
| Encodes | EST | fb52c01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64055 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192275 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214734 (1) | 1617 nt | ||
| Genomic | GenBank:BX548024 (1) | 218565 nt | ||
| Polypeptide | UniProtKB:Q7T373 (1) | 245 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Tessadori, F., de Bakker, D.E.M., Barske, L., Nelson, N., Algra, H.A., Willekers, S., Nichols, J.T., Crump, J.G., Bakkers, J. (2020) Zebrafish prrx1a mutants have normal hearts. Nature. 585:E14-E16
- Fazilaty, H., Rago, L., Kass Youssef, K., Ocaña, O.H., Garcia-Asencio, F., Arcas, A., Galceran, J., Nieto, M.A. (2019) A gene regulatory network to control EMT programs in development and disease. Nature communications. 10:5115
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Rago, L., Castroviejo, N., Fazilaty, H., Garcia-Asencio, F., Ocaña, O.H., Galcerán, J., Nieto, M.A. (2019) MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Developmental Cell. 51:446-459.e5
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