Gene
malt2
- ID
- ZDB-GENE-020801-2
- Name
- MALT paracaspase 2
- Symbol
- malt2 Nomenclature History
- Previous Names
-
- malt1
- malt1a
- paracaspace (1)
- pcasp1a
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to human MALT1 (MALT1 paracaspase).
- Genome Resources
- Note
-
Hulpiau, et al. (2016) demonstrate that this gene is orthologous to Malt2/Pcasp2 in chicken and turtle, and they suggest that mammals lost MALT2.
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR037940 | MALT1, death domain |
| Domain | IPR041077 | MALT1 immunoglobulin-like domain |
| Family | IPR052039 | Caspase-related proteases and regulators |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
| Homologous_superfamily | IPR033540 | MALT1, immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Caspase-like domain superfamily | Caspase-related proteases and regulators | Death-like domain superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | MALT1, death domain | MALT1 immunoglobulin-like domain | MALT1, immunoglobulin-like domain superfamily | Peptidase C14, caspase domain | Peptidase C14, p20 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DDL2
|
806 | |||||||||||||
|
UniProtKB:A0A8M2B8H7
|
802 |
Interactions and Pathways
No data available
Plasmids
No data available