Gene
pcdh10a
- ID
- ZDB-GENE-020731-1
- Name
- protocadherin 10a
- Symbol
- pcdh10a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within melanocyte migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; nervous system; neural crest; neural tube; and optic vesicle. Orthologous to human PCDH10 (protocadherin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu771 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Williams et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cadherin conserved site | Cadherin, cytoplasmic C-terminal domain | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NYV7
|
1001 | ||||||
|
UniProtKB:A0A8M3B7B9
|
955 | ||||||
|
UniProtKB:A0A2R8QI99
|
997 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh10a-201
(1)
|
Ensembl | 510 nt | ||
| mRNA |
pcdh10a-202
(1)
|
Ensembl | 752 nt | ||
| mRNA |
pcdh10a-203
(1)
|
Ensembl | 1,235 nt | ||
| mRNA |
pcdh10a-204
(1)
|
Ensembl | 3,566 nt | ||
| mRNA |
pcdh10a-205
(1)
|
Ensembl | 2,994 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-140O1 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-304L24 | ZFIN Curated Data | |
| Encodes | EST | eu771 | Thisse et al., 2005 | |
| Encodes | EST | fc56b06 | ||
| Encodes | EST | fq40g12 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:77378 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212571 (1) | 3590 nt | ||
| Genomic | GenBank:CU550698 (2) | 35511 nt | ||
| Polypeptide | UniProtKB:Q6NYV7 (1) | 1001 aa |
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
- Williams, J.S., Hsu, J.Y., Rossi, C.C., Artinger, K.B. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Developmental Biology. 444 Suppl 1:S274-S286
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Zhou, X., Yue, G.G., Liu, M., Zuo, Z., Lee, J.K., Li, M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J., Lau, C.B. (2016) Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget. 7(50):82820-82835
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
- Amo, R., Aizawa, H., Takahoko, M., Kobayashi, M., Takahashi, R., Aoki, T., and Okamoto, H. (2010) Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(4):1566-1574
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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