Gene
id3
- ID
- ZDB-GENE-020515-1
- Name
- inhibitor of DNA binding 3
- Symbol
- id3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein dimerization activity. Acts upstream of or within dopaminergic neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; germ ring; nervous system; polster; and presumptive ectoderm. Orthologous to human ID3 (inhibitor of DNA binding 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6899625 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA-binding protein inhibitor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:Q8QFX4
|
116 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160F23 | ZFIN Curated Data | |
| Encodes | EST | fa56g03 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6899625 | Thisse et al., 2004 | |
| Encodes | EST | tdsubc_2g3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76799 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174791 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152967 (1) | 1211 nt | ||
| Genomic | GenBank:AL935033 (2) | 162648 nt | ||
| Polypeptide | UniProtKB:Q8QFX4 (1) | 116 aa |
- Shih, H.Y., Chang, C.W., Chen, Y.C., Cheng, Y.C. (2023) Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish. International Journal of Molecular Sciences. 24(2):
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Paulissen, E., Martin, B.L. (2022) Myogenic regulatory factors myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting. Developmental Biology. 490:134-143
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
- Ren, J., Long, Y., Liu, R., Song, G., Li, Q., Cui, Z. (2021) Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. International Journal of Molecular Sciences. 22(6):
- Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M.T., Yang, H., Beffagna, G., Campanaro, S., Tam, W.L., Argenton, F., Lim, B., Korzh, V., Tiso, N. (2020) miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 9(3):
- Cang, Z., Nie, Q. (2020) Inferring spatial and signaling relationships between cells from single cell transcriptomic data. Nature communications. 11:2084
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
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