Gene
gpia
- ID
- ZDB-GENE-020513-2
- Name
- glucose-6-phosphate isomerase a
- Symbol
- gpia Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human GPI (glucose-6-phosphate isomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55667 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 4 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 4, glucose phosphate isomerase deficient | 613470 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018189 | Phosphoglucose isomerase, conserved site |
| Domain | IPR035476 | Phosphoglucose isomerase, SIS domain 1 |
| Domain | IPR035482 | Phosphoglucose isomerase, SIS domain 2 |
| Family | IPR001672 | Phosphoglucose isomerase (PGI) |
| Homologous_superfamily | IPR023096 | Phosphoglucose isomerase, C-terminal |
| Homologous_superfamily | IPR046348 | SIS domain superfamily |
Domain Details Per Protein
| Protein | Length | Phosphoglucose isomerase, conserved site | Phosphoglucose isomerase, C-terminal | Phosphoglucose isomerase (PGI) | Phosphoglucose isomerase, SIS domain 1 | Phosphoglucose isomerase, SIS domain 2 | SIS domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8QFU2
|
553 |
Interactions and Pathways
No data available
Plasmids
No data available