Gene
dtl
- ID
- ZDB-GENE-020419-34
- Name
- denticleless E3 ubiquitin protein ligase homolog (Drosophila)
- Symbol
- dtl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquitin-protein transferase activity. Involved in mitotic G2 DNA damage checkpoint and signal transduction involved in G2 DNA damage checkpoint. Predicted to localize to Cul4-RING E3 ubiquitin ligase complex; centrosome; and nucleus. Is expressed in several structures, including central nervous system; immature eye; mesoderm; optic primordium; and tail bud. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb151 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR051865 | WD repeat-containing CDT2 adapter protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat-containing CDT2 adapter protein |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RHI5
|
647 | ||||||
|
UniProtKB:A0A8M3B3Z8
|
646 |
Interactions and Pathways
No data available
Plasmids
No data available