Gene
atp6v0ca
- ID
- ZDB-GENE-020419-23
- Name
- ATPase H+ transporting V0 subunit ca
- Symbol
- atp6v0ca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable proton transmembrane transporter activity. Acts upstream of or within several processes, including apical protein localization; embryonic retina morphogenesis in camera-type eye; and notochord cell vacuolation. Predicted to be located in vacuolar membrane. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Is expressed in several structures, including digestive system; gonad; integument; nervous system; and unfertilized egg. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb993 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| early-onset epilepsy 3 | Alliance | Epilepsy, early-onset, 3, with or without developmental delay | 620465 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | F/V-ATP synthase subunit C superfamily | V-ATPase proteolipid subunit | V-ATPase proteolipid subunit C, eukaryotic | V-ATPase proteolipid subunit C-like domain |
|---|---|---|---|---|---|
|
UniProtKB:F1QSP4
|
154 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp6v0ca-201
(1)
|
Ensembl | 1,522 nt | ||
| mRNA |
atp6v0ca-202
(1)
|
Ensembl | 1,237 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81L17 | ZFIN Curated Data | |
| Encodes | BAC END | zk7n14 | ||
| Encodes | EST | cb993 | Thisse et al., 2001 | |
| Encodes | EST | fb57d09 | ||
| Encodes | STS | atp6l | ||
| Encodes | cDNA | MGC:76969 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174785 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173255 (1) | 1600 nt | ||
| Genomic | GenBank:CR387933 (1) | 182618 nt | ||
| Polypeptide | UniProtKB:F1QSP4 (1) | 154 aa |
- Levic, D.S., Ryan, S., Marjoram, L., Honeycutt, J., Bagwell, J., Bagnat, M. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. The Journal of cell biology. 219(4):
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dasgupta, S., Vliet, S.M., Kupsco, A., Leet, J.K., Altomare, D., Volz, D.C. (2017) Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. PeerJ. 5:e4156
- Sasaki, T., Lian, S., Khan, A., Llop, J.R., Samuelson, A.V., Chen, W., Klionsky, D.J., Kishi, S. (2017) Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy. 13(2):386-403
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gokey, J.J., Dasgupta, A., Amack, J.D. (2015) The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish. Developmental Biology. 407(1):115-30
- Ellis, K., Bagwell, J., and Bagnat, M. (2013) Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. The Journal of cell biology. 200(5):667-679
- Ramos-Balderas, J.L., Carrillo-Rosas, S., Guzman, A., Navarro, R.E., and Maldonado, E. (2013) The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype. BMC research notes. 6:39
- Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
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