Gene
tpi1b
- ID
- ZDB-GENE-020416-4
- Name
- triosephosphate isomerase 1b
- Symbol
- tpi1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have methylglyoxal synthase activity; protein homodimerization activity; and triose-phosphate isomerase activity. Predicted to be involved in several processes, including gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Is expressed in several structures, including brain; cardiovascular system; mesoderm; musculature system; and pleuroperitoneal region. Orthologous to human TPI1 (triosephosphate isomerase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb179 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| triosephosphate isomerase deficiency | Alliance | Hemolytic anemia due to triosephosphate isomerase deficiency | 615512 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020861 | Triosephosphate isomerase, active site |
| Family | IPR000652 | Triosephosphate isomerase |
| Family | IPR022896 | Triosephosphate isomerase, bacterial/eukaryotic |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR035990 | Triosephosphate isomerase superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Triosephosphate isomerase | Triosephosphate isomerase, active site | Triosephosphate isomerase, bacterial/eukaryotic | Triosephosphate isomerase superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IGG3
|
248 | |||||
|
UniProtKB:Q90XG0
|
248 |
Interactions and Pathways
No data available
Plasmids
No data available