Gene
sall1a
- ID
- ZDB-GENE-020228-2
- Name
- spalt-like transcription factor 1a
- Symbol
- sall1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including fin; nervous system; neural keel; neural tube; and tail bud. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome; middle lobe syndrome; and renal Wilms' tumor. Orthologous to human SALL1 (spalt like transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb896 (16 images)
- eu809 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| pfu1 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| pfu2 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| pfu3 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| sa11237 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38627 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40952 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Townes-Brocks syndrome | Alliance | Townes-Brocks branchiootorenal-like syndrome | 107480 |
| Townes-Brocks syndrome | Alliance | Townes-Brocks syndrome 1 | 107480 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sal C2H2-type zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:A0A1D5NSE4
|
1217 | |||
|
UniProtKB:F1QI36
|
1313 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sall1a-201
(1)
|
Ensembl | 6,552 nt | ||
| mRNA |
sall1a-202
(1)
|
Ensembl | 6,651 nt | ||
| mRNA |
sall1a-203
(1)
|
Ensembl | 3,974 nt | ||
| mRNA |
sall1a-204
(1)
|
Ensembl | 4,091 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-245J10 | ZFIN Curated Data | |
| Contains | SSLP | z26643 | Dildrop et al., 2004 | |
| Encodes | EST | cb896 | Thisse et al., 2001 | |
| Encodes | EST | eu809 | Thisse et al., 2005 | |
| Encodes | EST | ibd5077 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001146014 (1) | 5158 nt | ||
| Genomic | RefSeq:NW_018394702 (1) | 246692 nt | ||
| Polypeptide | UniProtKB:F1QI36 (1) | 1313 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SALL1 | 16 | Amino acid sequence comparison (3) Conserved genome location (synteny) (2) Nucleotide sequence comparison (1) | |
| Mouse | Sall1 | 8 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) Nucleotide sequence comparison (1) | |
| Fruit fly | salm | 2L | Nucleotide sequence comparison (1) Amino acid sequence comparison (1) |
- Peterson, E.A., Sun, J., Chen, X., Wang, J. (2024) Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Developmental Biology. 508:93-106
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Bruckner, J.J., Stednitz, S.J., Grice, M.Z., Zaidan, D., Massaquoi, M.S., Larsch, J., Tallafuss, A., Guillemin, K., Washbourne, P., Eisen, J.S. (2022) The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biology. 20:e3001838
- Yang, R., Zhan, M., Guo, M., Yuan, H., Wang, Y., Zhang, Y., Zhang, W., Chen, S., de The, H., Chen, Z., Zhou, J., Zhu, J. (2020) Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway. Cell death and differentiation. 28(1):170-183
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Reeves, W.M., Wu, Y., Harder, M.J., Veeman, M.T. (2017) Functional and evolutionary insights from the Ciona notochord transcriptome.. Development (Cambridge, England). 144:3375-3387
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938
- Harvey, S.A., and Logan, M.P. (2006) sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth. Development (Cambridge, England). 133(6):1165-1173
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