Gene

gria4a

ID

ZDB-GENE-020125-7

Name

glutamate receptor, ionotropic, AMPA 4a

Symbol

gria4a Nomenclature History

Previous Names

glur4a
gria4
zfGRIA4 (1)
iGluR4 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Localizes to dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in nervous system. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from Piller et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gria4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without seizures and gait abnormalities	617864

Associated With gria4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Ionotropic glutamate receptor	Ionotropic glutamate receptor, C-terminal	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:Q71E59 InterPro	898
UniProtKB:A0A8M9QLC3 InterPro	441
UniProtKB:A0A8M6Z9L8 InterPro	898
UniProtKB:A0A8M6Z4D2 InterPro	882
UniProtKB:A0A8M6Z2V5 InterPro	882