Gene
gria2a
- ID
- ZDB-GENE-020125-3
- Name
- glutamate receptor, ionotropic, AMPA 2a
- Symbol
- gria2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; mechanosensory lateral line system development; and neural crest cell development. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in nervous system. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu675 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language impairment and behavioral abnormalities | 618917 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI34
|
893 | ||||||
|
UniProtKB:A0A8M2BIL5
|
893 | ||||||
|
UniProtKB:Q71E63
|
875 | ||||||
|
UniProtKB:A0A8M2BI57
|
875 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gria2a-201
(1)
|
Ensembl | 1,044 nt | ||
| mRNA |
gria2a-202
(1)
|
Ensembl | 3,334 nt |
Interactions and Pathways
No data available
Plasmids
No data available