Gene
gria2a
- ID
- ZDB-GENE-020125-3
- Name
- glutamate receptor, ionotropic, AMPA 2a
- Symbol
- gria2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including embryonic cranial skeleton morphogenesis; mechanosensory lateral line system development; and neural crest cell development. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Is expressed in nervous system. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu675 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language impairment and behavioral abnormalities | 618917 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI34
|
893 | ||||||
|
UniProtKB:A0A8M2BIL5
|
893 | ||||||
|
UniProtKB:Q71E63
|
875 | ||||||
|
UniProtKB:A0A8M2BI57
|
875 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gria2a-201
(1)
|
Ensembl | 1,044 nt | ||
| mRNA |
gria2a-202
(1)
|
Ensembl | 3,334 nt |
Interactions and Pathways
No data available
Plasmids
No data available