Gene

gria1a

ID

ZDB-GENE-020125-1

Name

glutamate receptor, ionotropic, AMPA 1a

Symbol

gria1a Nomenclature History

Previous Names

glur1a
gria1.1
Gria1b (1)
zfGRIA1[a] (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Is expressed in nervous system. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gria1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 76	Alliance	?Intellectual developmental disorder, autosomal recessive 76	619931
		Intellectual developmental disorder, autosomal dominant 67	619927

Associated With gria1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I