Gene
per2
- ID
- ZDB-GENE-011220-2
- Name
- period circadian clock 2
- Symbol
- per2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Predicted to be active in cytoplasm and nucleus. Is expressed in heart; liver; muscle; nervous system; and ovary. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 1. Orthologous to human PER2 (period circadian regulator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb739 | Allele with one delins | Exon 10 | Unknown | CRISPR | |
| ihb740 | Allele with one deletion | Exon 10 | Unknown | CRISPR | |
| sa25916 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33027 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sus002 | Allele with one deletion | Unknown | Unknown | TALEN | |
| tlv02 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| tmd2 | Allele with one deletion | Unknown | Unknown | TALEN |
1 - 7 of 7
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| advanced sleep phase syndrome 1 | Alliance | ?Advanced sleep phase syndrome, familial, 1 | 604348 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PAS domain | PAS domain superfamily | PAS fold-3 | Period circadian-like, C-terminal | Period circadian protein homolog 1-3, PAS-A domain | Period circadian regulator |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QUT1
|
1399 | ||||||
|
UniProtKB:A0A8M9PS01
|
1417 | ||||||
|
UniProtKB:A0A8M9QFB2
|
1418 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.43per2:EGFP) |
|
| 1 | (3) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195J11 | ZFIN Curated Data | |
| Encodes | EST | fj43b09 | ||
| Encodes | EST | fl27h07 | ||
| Encodes | cDNA | MGC:195106 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182857 (1) | 5290 nt | ||
| Genomic | GenBank:BX890608 (1) | 194388 nt | ||
| Polypeptide | UniProtKB:A0A8M9QFB2 (1) | 1418 aa |
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Ding, H., Chen, X.C., Wan, L., Zhang, Y.Y., Rui, X.H., He, T., Liu, J., Shang, Z.B. (2024) Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues. Heliyon. 10:e30829e30829
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Zhao, W., Mao, L., He, C., Ding, D., Hu, N., Song, X., Long, D. (2023) Effects of low dose radiation on behavior rhythm of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 255:114779114779
- D'Agostino, Y., Frigato, E., Noviello, T.M.R., Toni, M., Frabetti, F., Cigliano, L., Ceccarelli, M., Sordino, P., Cerulo, L., Bertolucci, C., D'Aniello, S. (2022) Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience. 25:104054
- Dao, P., Hajny, S., Mekis, R., Orel, L., Dinhopl, N., Tessmar-Raible, K., Nowikovsky, K. (2022) The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. Life science alliance. 5(9)
1 - 10 of 119
Show