Gene
atic
- ID
- ZDB-GENE-011212-4
- Name
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
- Symbol
- atic Nomenclature History
- Previous Names
-
- cb72 (1)
- id:ibd1333
- wu:fb50b10
- wu:fb58a11
- wu:fi76g09
- wu:fy77g01
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Is expressed in several structures, including digestive system; immature eye; nervous system; neural crest; and yolk. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb72 (12 images)
- IMAGE:6907237 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| AICA-ribosiduria due to ATIC deficiency | 608688 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011607 | Methylglyoxal synthase-like domain |
| Family | IPR002695 | Bifunctional purine biosynthesis protein PurH-like |
| Homologous_superfamily | IPR016193 | Cytidine deaminase-like |
| Homologous_superfamily | IPR024050 | AICAR transformylase, insert domain superfamily |
| Homologous_superfamily | IPR024051 | AICAR transformylase, duplicated domain superfamily |
| Homologous_superfamily | IPR036914 | Methylglyoxal synthase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AICAR transformylase, duplicated domain superfamily | AICAR transformylase, insert domain superfamily | Bifunctional purine biosynthesis protein PurH-like | Cytidine deaminase-like | Methylglyoxal synthase-like domain | Methylglyoxal synthase-like domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DKL0
|
590 |
Interactions and Pathways
No data available
Plasmids
No data available