Gene

gc2

ID

ZDB-GENE-011128-8

Name

guanylyl cyclase 2

Symbol

gc2 Nomenclature History

Previous Names

Gucy2f (1)
RETGC-2 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to localize to plasma membrane. Is expressed in retina and retinal outer nuclear layer. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gc2 Human Ortholog

No data available

Associated With gc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR011645	Haem NO binding associated
Family	IPR050401	Cyclic nucleotide synthase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR029787	Nucleotide cyclase