Gene
tnfsf10l
- ID
- ZDB-GENE-010801-1
- Name
- TNF superfamily member 10, like
- Symbol
- tnfsf10l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including adaxial cell; central nervous system; endoderm; germ ring; and head. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu256 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tumour necrosis factor domain | Tumour necrosis factor ligand 10/11 | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|
|
UniProtKB:Q7ZYX9
|
317 | |||
|
UniProtKB:A0A8M2BK35
|
316 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfsf10l-201
(1)
|
Ensembl | 6,053 nt | ||
| mRNA |
tnfsf10l-202
(1)
|
Ensembl | 791 nt | ||
| mRNA |
tnfsf10l-204
(1)
|
Ensembl | 2,439 nt | ||
| ncRNA |
tnfsf10l-002
(1)
|
Ensembl | 758 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-171C9 | ZFIN Curated Data | |
| Contains | SNP | rs3728037 | ZFIN Curated Data | |
| Encodes | EST | eu256 | Thisse et al., 2005 | |
| Encodes | EST | fc12f06 | Bobe et al., 2001 | |
| Encodes | cDNA | MGC:55195 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131843 (1) | 2696 nt | ||
| Genomic | GenBank:CR381635 (1) | 173058 nt | ||
| Polypeptide | UniProtKB:Q7ZYX9 (1) | 317 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | TNFSF10 | 3 | Amino acid sequence comparison (1) |
- Ribas, L., Liew, W.C., Díaz, N., Sreenivasan, R., Orbán, L., Piferrer, F. (2017) Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 114(6):E941-E950
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J., Dong, C. (2015) Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish & shellfish immunology. 45(2):757-70
- Wiens, G.D., and Glenney, G.W. (2011) Origin and evolution of TNF and TNF receptor superfamilies. Developmental and comparative immunology. 35(12):1324-35
- Chang, M.X., Nie, P., Xie, H.X., Wang, G.L., and Gao, Y. (2006) Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 110(1-2):51-63
- Eimon, P.M., Kratz, E., Varfolomeev, E., Hymowitz, S.G., Stern, H., Zha, J., and Ashkenazi, A. (2006) Delineation of the cell-extrinsic apoptosis pathway in the zebrafish. Cell death and differentiation. 13(10):1619-1630
- Kratz, E., Eimon, P.M., Mukhyala, K., Stern, H., Zha, J., Strasser, A., Hart, R., and Ashkenazi A. (2006) Functional characterization of the Bcl-2 gene family in the zebrafish. Cell death and differentiation. 13(10):1631-1640
- Correa, R.G., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C., and Verma, I.M. (2005) Zebrafish IkappaB Kinase 1 Negatively Regulates NF-kappaB Activity. Current biology : CB. 15(14):1291-1295
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Zhang, C., Willett, C., and Fremgen, T. (2003) Zebrafish: An animal model for toxicological studies. Current Protocols in Toxicology. Unit 1.7
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